New Technologies Reduce the Risk of Esophageal Cancer in Barrett’s Esophagus

Principal Investigator: Sri Komanduri, MD | Co- Principal Investigator: Domenico Farina, MD Esophageal cancer is a deadly and increasingly common disease in the United States. Up to 15 percent of patients with gastro-esophageal reflux disease (GERD) will develop Barrett’s esophagus (BE), a pre-cancerous state that can develop into esophageal cancer. While BE is highly treatable, the progression to esophageal cancer still commonly occurs due to missed detection and diagnosis of Barrett’s esophagus, which often returns despite treatment. A new technology, Wide-Area Trans-Epithelial Sampling (WATS-3D), may offer improved detection of abnormal cells (dysplasia) in Barrett’s. WATS-3D uses brush sampling to examine larger areas of the esophagus than is achieved in conventional biopsies. Preliminary studies show improved detection of cancerous changes in Barrett’s esophagus surveillance. Dr. Komanduri’s team hopes to determine if the addition of WATS-3D increases the rate of detection of recurrent Barrett’s following treatment. If so, this could be a game changer for patients, allowing for earlier re-treatment of Barrett’s and, ultimately, for the prevention of esophageal...

Using a Video Education Tool to Impact Patient Satisfaction and Perceptions of Cancer Risks for Patients with Barrett’s Esophagus

Principal Investigator: Amanda Guentner, MD No one wants to hear the “C” word. Even the slightest hint of a cancer risk is, understandably, frightening—even when all signs point to a positive outcome. Chronic regurgitation of stomach acid can damage the esophagus and eventually lead to a condition known as Barrett’s esophagus (BE). Patients with BE are at risk for esophageal adenocarcinoma (cancer of the esophagus), which strikes about 3 to 4 Americans out of 100,000 each year. While a variety of advanced treatments such as endoscopic eradication therapy (EET) help to prevent cancer well before it ever starts, many patients overestimate their cancer risk. Being referred for treatment appears to further ramp up their anxiety. Despite patient education prior to and after EET, individuals facing a series of treatments often forget what they may have been told about their diagnosis, cancer risk and/or short- and long-term prognosis. This perceived lack of information, which has been linked to overall patient satisfaction, often pushes them over the top. Supported by the Digestive Health Foundation, researchers in Northwestern Medicine’s Division of Gastroenterology and Hepatology are evaluating the use of multimedia to enhance the patient experience pre- and post-EET therapy. Recent studies have shown them to be successful with patients who’ve undergone general and orthopaedic surgical procedures. The investigators plan to create an educational video for patients undergoing EET for Barrett’s esophagus through Northwestern’s Digestive Health Center and measure its impact on reducing patient anxiety. Led by GI fellow Amanda Guentner, MD, the team will produce a short video to reinforce the information patients typically receive during face-to-face consultations with their gastroenterologist and/or...