Ongoing Research Funded by DHF

Introducing a groundbreaking new research technology, the

Since 2015, DHF has raised over $3.0 million and funded over 20 cutting-edge research studies that are changing the future of digestive health.

To view the original scientific abstracts from the researchers, CLICK HERE.

2017

Neutrophil microRNAs Promote Genomic Instability and Carcinogenesis in Inflamed Intestinal Tissue

Principal Investigator: Ronen Sumagin, PhD Normally immune cells like polymorphonuclear neutrophils (PMNs) protect our body against invading pathogens, but sometimes
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A Multidisciplinary Collaboration to Minimize Diversion of Opioids

Principal Investigator: Jonah J. Stulberg, MD, PhD, MPH A surplus of prescription pain killers continues to fuel the drug crisis
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Bowel Purge and Change in Pulmonary Function Tests in People with Cystic Fibrosis: A Pilot Study

Principal Investigator: Adam C. Stein, MD Does constipation cause breathing problems? In some individuals with cystic fibrosis (CF), the answer
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Metabolomic Biomarkers for the Diagnosis of NASH in the Liver Transplant Population

Principal Investigator: Mary Rinella, MD The most common cause of liver injury in the United States, non-alcoholic fatty liver disease
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Perioperative Lidocaine Pharmacokinetics in Patients Receiving Intravenous Lidocaine Analgesia during and after Colorectal Surgery

Principal Investigator: Shireen Ahmad, MD More than 300 patients undergo bowel surgery every year at Northwestern Memorial Hospital for a
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The Effect of a Colonoscopy Skills Report Card on Colonoscopy Technique

Principal Investigator: Anna Duloy, MD Skills matter when it comes to screening colonoscopies for colon cancer, the second-leading cause of
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Assessment of Subclinical Inflammation in Patients with Inflammatory Bowel Disease Who Use Cannabis

Principal Investigator: Madeline McGuire Bertha, MD, MS Medical marijuana use has grown among patients attempting to tamp down the debilitating
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A Collaborative Study to Evaluate the Efficacy of Prospective Post-Induction Infliximab Dosing Based on Trough Levels at Week 12 and 28 in subjects with Crohn’s Disease and Ulcerative Colitis

Principal Investigator: Emanuelle Araujo Lima Bellaguarda, MD The drug infliximab (Remicade) offers relief to millions of people with Crohn’s disease
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Optimizing Patient Outcomes through Early Detection of Uncontrolled Acid Reflux after Endoscopic Therapy for Pre-Cancerous Lesions in the Setting of Barrett’s Esophagus

Principal Investigator: Sri Komanduri, MD Barrett’s Esophagus (BE) occurs when damaging acid reflux causes the lining of the esophagus to
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Molecular Profiling and Associations with Clinical Phenotypes in Adult Eosinophilic Esophagitis

Principal Investigator:  Nirmala Gonsalves, MD Previously thought to be a rare disorder, Eosinophilic Esophagitis (EoE) has emerged as a common
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2016

Utilization of Video-Based Education through the Patient Portal to Improve Adherence to Colorectal Cancer Screening

Screening colonoscopies have been credited with turning the tide against colorectal cancer—the second leading cause of death in the United States—with early prevention and treatment. Yet barriers, from patient fears to cultural influences, keep many Americans from undergoing the potentially lifesaving procedure. Even when screening colonoscopies are scheduled, no shows and cancellations are common.
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Video Case Series with 3D Animation for Endoscopic Submucosal Endoscopy (ESD) Strategies

From development to implementation, new medical advancements often don’t enter into mainstream usage without education and training. Introduced in the 1990s in Japan, minimally-invasive endoscopic submucosal dissection (ESD) has become the standard of care for not only treating but also, most importantly, curing early gastrointestinal cancers.
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Semen Quality in Males with Inflammatory Bowel Disease: Influence of Methotrexate Treatment

Immunosuppressive drugs have made living with inflammatory bowel disease (IBD) easier. But these powerful medications have their drawbacks, especially when it comes to potentially affecting future fertility. Complicating matters, IBD often strikes people during their key reproductive years. Patients’ fertility fears may dissuade them from taking effective medication that could help them to better manage their disease.
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The Impact of a Video Educational Tool on Perceived Cancer Risk in Patients with Barrett’s Esophagus

No one wants to hear the “C” word. Even the slightest hint of a cancer risk is, understandably, frightening—even when all signs point to a positive outcome. Chronic regurgitation of stomach acid can damage the esophagus and eventually lead to a condition known as Barrett’s esophagus (BE). Patients with BE are at risk for esophageal adenocarcinoma (cancer of the esophagus), which strikes about 3 to 4 Americans out of 100,000 each year.
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HepQuant Liver Function Testing in the Prediction of Outcomes

Many babies born with heart problems grow up and mature well into adulthood thanks to modern surgical advancements. In fact, one million adults currently live with some form of congenital heart disease in the United States alone. A rare congenital heart condition, single ventricle disease usually requires surgical intervention early on, with most children undergoing a common surgery known as the Fontan procedure.
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Health Coaching to Enhance Effectiveness of Behavioral Interventions for Chronic Digestive Conditions

Behavioral interventions for digestive health conditions are highly effective, yet while the majority of patients are interested in these treatments, there are many barriers to accessing this care. Integrating health coaching to assist patients in make lifestyle changes and managing their health conditions may increase access to care by reducing the number of sessions needed with GI health psychologists.
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2015

Enhancing Physician Competency for High-Resolution Esophageal Manometry: Developing a High-Quality Standardized Training System & Measuring Physician Learning Curves

Every physician strives for and every patient expects an accurate diagnosis—no matter what the health issue. Advancements in imaging and other technologies continue to enhance diagnostic capabilities for a range of diseases, including gastrointestinal disorders. But even the most sophisticated diagnostic tools can yield erroneous results in untrained and/or inexperienced hands.
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Pharmacogenomic Polymorphisms and Clinical Outcomes in Liver Transplant Recipients

Variations in our genetic makeup determine who we are, from hair and eye color to how we respond to drugs. Today, the growing field of personalized medicine looks to our DNA to tailor treatment so that we receive precise and appropriate care. An emerging offshoot, pharmacogenomics looks specifically at the connections between genetics and drug metabolism.
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Improving Care Integration of Youth with IBD Using Stakeholder Input

Graduating from high school. Going away to college. Getting that first job. For many, these milestones mark the transition from childhood to adulthood, with parents and their children diligently preparing for them as they arise. Yet a young adult patient’s move from beloved pediatrician or family doctor to an unfamiliar adult care specialist is often abrupt. Learning to be in charge of your own health can be challenging, especially for those with chronic illnesses.
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Evaluation of the esophagogastric junction in gastroesophageal reflux disease using the Functional Lumen Imaging Probe.

Gastroesophageal reflux disease (GERD) is a common condition that often involves heartburn and/or regurgitation. If left untreated, scarring of the esophagus or “food pipe” may result. GERD leads to millions of outpatient visits annually. For some individuals, increased laxity at the end of the muscular esophagus may contribute to GERD. Assessing the extent of this laxity helps to determine the most appropriate strategies for treating the disease and preventing further damage to the esophagus.
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