Ongoing Research Funded by DHF

Predicting Symptom Improvement after Novel Endoscopic Treatment for Gastroparesis

2021  | Disease: GastroparesisGeneral Gastroenterology

Principal Researcher: Aziz Aadam, MD

Co-Principal Researcher: Darren M. Brenner | 

Principal Investigator: Aziz Aadam, MD

Gastroparesis is a debilitating condition that can cause persistent nausea, vomiting, and abdominal pain due to delayed stomach (gastric) emptying. The inability to eat or drink can lead to malnutrition and reduced quality of life. Current treatments are limited in both effectiveness and durability. A minimally invasive endoscopic procedure called G-POEM has recently shown promise in improving spasms of the sphincter muscle that prevent proper gastric emptying. G-POEM involves cutting this smooth band of muscle—that connects the stomach to the small intestine—to prevent further spasms and to allow the stomach to empty. Dr. Cai hopes to identify which gastroparesis patients would most likely benefit from this treatment using two novel methods: EndoFLIP, a probe that measures sphincter flexibility and antroduodenal manometry (ADM), a catheter that measures pressures throughout the upper gastrointestinal tract. Her team will look for specific EndoFLIP and ADM metrics that can be used to more effectively select patients for and predict improvement after G-POEM.

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