Examining whether a stent helps stomach emptying after cutting the pylorus muscle in patients with delayed stomach emptying

Principal Investigator: Aziz Aadam, MD; Co-Principal Investigator: Kevin Liu, MD

Gastroparesis is a condition when the stomach does not empty correctly due to lack of stomach muscle coordination.  Many patients with chronic gastroparesis experience symptoms ranging from persistent nausea and vomiting to the inability to eat or drink. Lacking effective treatment options, patients with gastroparesis are at risk for inadequate nutrition and repeated hospitalizations. Endoscopic targeted therapies including placement of a tube to allow the stomach to empty into the small intestine (transpyloric stent) and G-POEM, an advanced minimally invasive procedure to cut the sphincter muscle in the pylorus, have recently shown promise by improving gastric emptying for patients.  The Aadam team intends to examine whether patients who improve with transpyloric stenting, which provides temporary relief, will also demonstrate improvement with G-POEM, which can provide a more durable, long-lasting solution. Northwestern is one of the few centers in the nation performing G-POEM and has one of the highest volumes for both advanced endoscopic therapies. This study offers great potential for significantly impacting this patient population.


Posted on

April 29, 2019