Ongoing Research Funded by DHF

How Does Inflammation Affect the Development and Progression of Eosinophilic Esophagitis?

2019  | Disease: Esophageal DiseasesEosinophilic Esophagitis (EoE)

Principal Researcher: Marie-Pier Tétreault, PhD

Co-Principal Researcher: Katie Hulse, PhD | 

Principal Investigator: Marie-Pier Tétreault, PhD

The epithelial lining of the esophagus serves as the first line of defense to protect the underlying tissue from various external insults. Upon injury and inflammation, a rapid and efficient restoration of the esophageal epithelial barrier is needed. Failure to restore this barrier ultimately leads to pathological consequences. To date, most studies of inflammation have focused in immune cells because they are the paradigmatic inflammatory cell type. Yet immune cells are not the only cell type involved in inflammation and immunity. Epithelial cells sense and initiate inflammation, and also play a key role in the production of inflammatory molecules. It still remains unclear, though, how epithelial cells contribute to inflammation in patients with Eosinophilic Esophagitis (EoE). The investigators will determine how epithelial cells control inflammation and
fibrosis in eosinophilic esophagitis. The Tétreault laboratory will also test how blocking mediators of inflammation can prevent the development and progression of EoE.

To receive Digestive Health Foundation updates on research, free education events, and the 2019 Gala, please fill in your information and click 'Submit.'

Thank you, and welcome!

We will not give or sell your contact information to anyone and will only send communications to your inbox when we have exciting news or events to share.