Ongoing Research Funded by DHF

p53 Mutation Spectrum (Occurrence) and Load (Genotype Damage) in Ulcerative Colitis

2021  | Disease: Crohn's Disease (CD) and Ulcerative Colitis (UC)Inflammatory Bowel Disease (IBD)

Principal Researcher: Guang-Yu Yang, MD, PhD

Co-Principal Researcher: David Escobar, MD, PhD | Co-Principal Researcher: Stephen B. Hanauer, MD | Co-Principal Researcher: Leyu Sun | 

Principal Investigator: Guang-Yu Yang, MD

Chronic inflammation is an important risk factor for cancer. Patients with ulcerative colitis (UC) face a significantly increased risk of developing colorectal cancers. Damaged DNA and genetic alterations can be caused by the inflammatory process. Identifying crucial inflammation-associated molecular events offers potential targets to predict and prevent cancers. Missense p53 mutations are one of the most common and earliest molecular events seen in UC-associated carcinogenesis. Yet little is known about the evolution of p53 mutations during the long-term course of UC and whether targeting these mutations will have an impact on the long-term cancer risk in patients with UC. Employing a next-generation sequencing approach, Dr. Yang’s study aims to determine the mutation spectrum and load of the p53 gene in this patient population. The researchers intend to identify whether specific p53 mutations are critical in driving UC-induced carcinogenesis, and to evaluate its role as an efficient biomarker for predicting the risk of cancer development in UC patients.

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